<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Evidente, Antonio</style></author><author><style face="normal" font="default" size="100%">Masi, Marco</style></author><author><style face="normal" font="default" size="100%">Linaldeddu, Benedetto T.</style></author><author><style face="normal" font="default" size="100%">Franceschini, Antonio</style></author><author><style face="normal" font="default" size="100%">Scanu, Bruno</style></author><author><style face="normal" font="default" size="100%">Cimmino, Alessio</style></author><author><style face="normal" font="default" size="100%">Andolfi, Anna</style></author><author><style face="normal" font="default" size="100%">Motta, Andrea</style></author><author><style face="normal" font="default" size="100%">Maddau, Lucia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Afritoxinones A and B, dihydrofuropyran-2-ones produced by Diplodia africana the causal agent of branch dieback on Juniperus phoenicea</style></title><secondary-title><style face="normal" font="default" size="100%">PHYTOCHEMISTRY</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Afritoxinones A and B</style></keyword><keyword><style  face="normal" font="default" size="100%">Botryosphaeriaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Diplodia africana</style></keyword><keyword><style  face="normal" font="default" size="100%">Juniperus phoenicea</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytotoxins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2012///</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">77</style></volume><pages><style face="normal" font="default" size="100%">245 - 250</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Two phytotoxic dihydrofuropyran-2-ones, named afritoxinones A and B. were isolated from liquid culture of Diplodia africana. a fungal pathogen responsible for branch dieback of Phoenicean juniper in Italy. Additionally, six others known metabolites were isolated and characterized: oxysporone, sphaeropsidin A, epi-sphaeropsidone, R-(-)-mellein, (3R,4R)-4-hydroxymellein and (3R,4S)-4-hydroxymellein. The structures of afritoxinones A and B were established by spectroscopic and optical methods and determined to be as (3aS{*},6R{*}-,7aS)-6-methoxy-3a,7a-dihydro-3H,6H-furo\{[\}2,3-b]pyran-2-o ne and (3aR{*},6R{*},7aS)-6-methoxy-3a,7a-dihydro-3H,6H-furo\{[\}2,3-b]pyran-2-on e, respectively. The phytotoxic activity of afritoxinones A and B and oxysporone was evaluated on host (Phoenicean juniper) and non-host plant (holm oak, cork oak and tomato) by cutting and leaf puncture assay. Oxysporone proved to be the most phytotoxic compound. This study represents the first report of secondary metabolites produced by D. africana. In addition, the taxonomic implications of secondary metabolites in Botryosphaeriaceae family studies are discussed. (C) 2012 Elsevier Ltd. All rights reserved.</style></abstract><notes><style face="normal" font="default" size="100%">The following values have no corresponding Zotero field:&lt;br/&gt;pub-location: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND&lt;br/&gt;publisher: PERGAMON-ELSEVIER SCIENCE LTD</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Evidente, Antonio</style></author><author><style face="normal" font="default" size="100%">Maddau, Lucia</style></author><author><style face="normal" font="default" size="100%">Scanu, Bruno</style></author><author><style face="normal" font="default" size="100%">Andolfi, Anna</style></author><author><style face="normal" font="default" size="100%">Masi, Marco</style></author><author><style face="normal" font="default" size="100%">Motta, Andrea</style></author><author><style face="normal" font="default" size="100%">Tuzi, Angela</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Sphaeropsidones, Phytotoxic Dimedone Methyl Ethers Produced by Diplodia cupressi: A Structure−Activity Relationship Study</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Natural Products</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antifungal activity (voyant)</style></keyword><keyword><style  face="normal" font="default" size="100%">Diplodia cupressi</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Sphaeropsidones</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011///</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1021/np100837r</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">74</style></volume><pages><style face="normal" font="default" size="100%">757 - 763</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Sphaeropsidone and episphaeropsidone are two phytotoxic dimedone methyl ethers produced by Diplodia cupressi, the causal agent of a canker disease of cypress in the Mediterranean area. In this study, eight derivatives obtained by chemical modifications and two natural analogues were assayed for phytotoxic and antifungal activities, and a structure?activity relationship was examined. Each compound was tested on nonhost plants and on five fungal pathogenic species belonging to the genus Phytophthora. The results provide insights into structure?activity relationships within these compounds. It was found that the hydroxy group at C-5, the absolute C-5 configuration, the epoxy group, and the C-2 carbonyl group appear to be structural features important in conferring biological activity. The conversion of sphaeropsidone into the corresponding 1,4-dione derivative led to a compound showing greater antifungal activity than its precursor. This finding could be useful in devising new natural fungicides for practical application in agriculture.</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><notes><style face="normal" font="default" size="100%">doi: 10.1021/np100837rdoi: 10.1021/np100837rThe following values have no corresponding Zotero field:&lt;br/&gt;publisher: American Chemical Society</style></notes></record></records></xml>