<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Custódio, Luísa</style></author><author><style face="normal" font="default" size="100%">Patarra, João</style></author><author><style face="normal" font="default" size="100%">Alberício, Fernando</style></author><author><style face="normal" font="default" size="100%">Neng, Nuno Da Rosa</style></author><author><style face="normal" font="default" size="100%">Nogueira, José Manuel Florêncio</style></author><author><style face="normal" font="default" size="100%">Romano, Anabela</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phenolic composition, antioxidant potential and in vitro inhibitory activity of leaves and acorns of Quercus suber on key enzymes relevant for hyperglycemia and Alzheimer's disease</style></title><secondary-title><style face="normal" font="default" size="100%">Industrial Crops and Products</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alzheimer’s  disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Cholinesterase</style></keyword><keyword><style  face="normal" font="default" size="100%">Cork  oak</style></keyword><keyword><style  face="normal" font="default" size="100%">Dementia</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurological  disorders</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year></dates><publisher><style face="normal" font="default" size="100%">Elsevier B.V.</style></publisher><volume><style face="normal" font="default" size="100%">64</style></volume><pages><style face="normal" font="default" size="100%">45-51</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">This work reports the in vitro antioxidant and inhibitory activities of hexane, methanol and water extracts of cork oak (Quercus suber) against acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), a-amylase and a-glucosidase. The total content of phenolics (TPC), tannins (TTC) and flavonoids (TFC), and the HPLC profile of the main phenolic compounds present in the extracts, were also determined. In the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay the best results were obtained with the methanol and water extracts from both leaves and acorns (41–49%). In the 2,2 a-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) method the highest activity was observed with the methanol and leaf water extracts (63–71%). The most significant effects on cholinesterase activity were obtained with the methanol leaf extract at the concentration of 1 mg/mL, yielding inhibition values of 79 and 80% on AChE and BuChE, respectively. No relevant activity was detected against a-amylase, but samples significantly inhibited a-glucosidase from baker’s yeast, and the best results were obtained with the water and methanol leaf extracts with values of 97 and 89%, respectively, higher than the positive controls used (acarbose and glucobay). The methanol leaf extract had the highest TPC (211 mg GAE/g, DW) and TFC (8.2 mg RE/g, DW), whereas the water extracts had the highest tannin levels (87 CE/g, DW). The main compound in the methanol leaf extract was gentisic acid (24.3 mg/g, DW). Our results suggest that leaves and acorns from cork oak contain compounds useful for alleviating symptoms associated with Alzheimer disease and other neurodegenerative ailments as well as diabetes.</style></abstract></record></records></xml>