<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fernandes, Ana</style></author><author><style face="normal" font="default" size="100%">Fernandes, Iva</style></author><author><style face="normal" font="default" size="100%">Cruz, Luís Luís</style></author><author><style face="normal" font="default" size="100%">Mateus, Nuno</style></author><author><style face="normal" font="default" size="100%">Cabral, Miguel</style></author><author><style face="normal" font="default" size="100%">de Freitas, Victor</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Biological Properties of Bioactive Phenolic Compounds from Quercus suber L.</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Agricultural and Food Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants: isolation &amp; purification</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants: pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Antitumor activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Proliferation</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Proliferation: drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Cork</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrolyzable Tannins</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrolyzable Tannins: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrolyzable Tannins: isolation &amp; purification</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrolyzable Tannins: pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">phenolic compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts: isolation &amp; purification</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts: pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercus</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercus suber L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercus: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2009///</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/19888728http://dx.doi.org/10.1021/jf902093m</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">57</style></volume><pages><style face="normal" font="default" size="100%">11154 - 11160</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Phenolic compounds, namely, hydrolyzable tannins and low molecular weight phenolic compounds, were isolated and purified from Portuguese cork from Quercus suber L. Some of these compounds were studied to evaluate their antioxidant activity, including free-radical scavenging capacity (DPPH method) and reducing capacity (FRAP method). All compounds tested showed significant antioxidant activity, namely, antiradical and reducing properties. The antiradical capacity seemed to increase with the presence of galloyl groups. Regarding the reducing capacity, this structure-activity relationship was not so clear. These compounds were also studied to evaluate the growth inhibitory effect on the estrogen responsive human breast cancer cell line (ERþ) MCF-7 and two other colon cancer cell lines (Caco-2 and HT-29). Generally, all the compounds tested exhibited, after a continuous exposure during a 48 h period, a dose-dependent growth inhibitory effect. Relative inhibitory activity was primarily related to the number of phenolic hydroxyl groups (galloyl and HHDP moieties) found in the active structures, with more groups generally conferring increased effects, except for HHDP-di-galloyl-glucose. Mongolicain B showed a greater potential to inhibit the growth of the three cell lines tested, identical to the effect observed with castalagin. Since these compounds are structurally related with each other, this activity might be based within the C-glycosidic ellagitannin moiety.</style></abstract><issue><style face="normal" font="default" size="100%">23</style></issue><notes><style face="normal" font="default" size="100%">From Duplicate 2 (Antioxidant and Biological Properties of Bioactive Phenolic Compounds from Quercus suber L. - Fernandes, Ana; Fernandes, Iva; Cruz, Luís; Mateus, Nuno; Cabral, Miguel; de Freitas, Victor)From Duplicate 2 (Antioxidant and Biological Properties of Bioactive Phenolic Compounds from Quercus suber L. - Fernandes, Ana; Fernandes, Iva; Cruz, Luís; Mateus, Nuno; Cabral, Miguel; de Freitas, Victor)The following values have no corresponding Zotero field:&lt;br/&gt;publisher: American Chemical Society&lt;br/&gt;accession-num: 19888728</style></notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fernandes, Ana</style></author><author><style face="normal" font="default" size="100%">Fernandes, Iva</style></author><author><style face="normal" font="default" size="100%">Cruz, Luís Luís</style></author><author><style face="normal" font="default" size="100%">Mateus, Nuno</style></author><author><style face="normal" font="default" size="100%">Cabral, Miguel</style></author><author><style face="normal" font="default" size="100%">de Freitas, Victor</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Biological Properties of Bioactive Phenolic Compounds from Quercus suber L.</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Agricultural and Food Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants: isolation &amp; purification</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants: pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Antitumor activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Proliferation</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Proliferation: drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Cork</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrolyzable Tannins</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrolyzable Tannins: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrolyzable Tannins: isolation &amp; purification</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrolyzable Tannins: pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">phenolic compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts: isolation &amp; purification</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts: pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercus</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercus suber L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercus: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year></dates><publisher><style face="normal" font="default" size="100%">American Chemical Society</style></publisher><volume><style face="normal" font="default" size="100%">57</style></volume><pages><style face="normal" font="default" size="100%">11154-11160</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Phenolic compounds, namely, hydrolyzable tannins and low molecular weight phenolic compounds, were isolated and purified from Portuguese cork from Quercus suber L. Some of these compounds were studied to evaluate their antioxidant activity, including free-radical scavenging capacity (DPPH method) and reducing capacity (FRAP method). All compounds tested showed significant antioxidant activity, namely, antiradical and reducing properties. The antiradical capacity seemed to increase with the presence of galloyl groups. Regarding the reducing capacity, this structure-activity relationship was not so clear. These compounds were also studied to evaluate the growth inhibitory effect on the estrogen responsive human breast cancer cell line (ERþ) MCF-7 and two other colon cancer cell lines (Caco-2 and HT-29). Generally, all the compounds tested exhibited, after a continuous exposure during a 48 h period, a dose-dependent growth inhibitory effect. Relative inhibitory activity was primarily related to the number of phenolic hydroxyl groups (galloyl and HHDP moieties) found in the active structures, with more groups generally conferring increased effects, except for HHDP-di-galloyl-glucose. Mongolicain B showed a greater potential to inhibit the growth of the three cell lines tested, identical to the effect observed with castalagin. Since these compounds are structurally related with each other, this activity might be based within the C-glycosidic ellagitannin moiety.</style></abstract><accession-num><style face="normal" font="default" size="100%">19888728</style></accession-num><notes><style face="normal" font="default" size="100%">From Duplicate 2 (Antioxidant and Biological Properties of Bioactive Phenolic Compounds from Quercus suber L. - Fernandes, Ana; Fernandes, Iva; Cruz, Luís; Mateus, Nuno; Cabral, Miguel; de Freitas, Victor)</style></notes><research-notes><style face="normal" font="default" size="100%">From Duplicate 2 (Antioxidant and Biological Properties of Bioactive Phenolic Compounds from Quercus suber L. - Fernandes, Ana; Fernandes, Iva; Cruz, Luís; Mateus, Nuno; Cabral, Miguel; de Freitas, Victor)</style></research-notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Khennouf, Seddik</style></author><author><style face="normal" font="default" size="100%">Benabdallah, Hassiba</style></author><author><style face="normal" font="default" size="100%">Gharzouli, Kamel</style></author><author><style face="normal" font="default" size="100%">Amira, Smain</style></author><author><style face="normal" font="default" size="100%">Ito, Hideyuki</style></author><author><style face="normal" font="default" size="100%">Kim, Tae-Hoon</style></author><author><style face="normal" font="default" size="100%">Yoshida, Takashi</style></author><author><style face="normal" font="default" size="100%">Gharzouli, Akila</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Tannins from Quercus suber and Quercus coccifera Leaves on Ethanol-Induced Gastric Lesions in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Agricultural and Food Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetone</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Biphenyl Compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">castalagin</style></keyword><keyword><style  face="normal" font="default" size="100%">Catechols</style></keyword><keyword><style  face="normal" font="default" size="100%">Catechols: therapeutic use</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Experimental gastric ulcer</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrolyzable Tannins</style></keyword><keyword><style  face="normal" font="default" size="100%">lipid peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid Peroxidation: drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts: therapeutic use</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Leaves: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercus</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercus sp.</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercus: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Rabbits</style></keyword><keyword><style  face="normal" font="default" size="100%">Stomach Ulcer</style></keyword><keyword><style  face="normal" font="default" size="100%">Stomach Ulcer: chemically induced</style></keyword><keyword><style  face="normal" font="default" size="100%">Stomach Ulcer: prevention &amp; control</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannins</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannins: pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannins: therapeutic use</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2003</style></year></dates><publisher><style face="normal" font="default" size="100%">American Chemical Society</style></publisher><volume><style face="normal" font="default" size="100%">51</style></volume><pages><style face="normal" font="default" size="100%">1469-1473</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The gastroprotective effects of 70% acetone extracts of Quercus suber and Quercus coccifera leaves and of tannins (pedunculagin, castalagin, phillyraeoidin A, and acutissimin B) purified from these extracts were examined in the mouse using the ethanol-induced gastric ulcer model. Both extracts (25, 50, and 100 mg/kg), given orally, prevented the formation of ethanol-induced lesions in the stomach. The percent protection varied between 68 and 91%. Purified tannins (50 mg/kg) were also effective in protecting the stomach against ethanol, and the percent protection varied from 66 to 83%. Castalagin was the most potent. Both extracts and all of the tannins tested (10, 25, and 50 ?g/mL) strongly inhibited (55?65%) the lipid peroxidation of rabbit brain homogenate. These results suggest that the gastroprotective effects of extracts of Q. suber and Q. coccifera leaves and the purified tannins in this experimental model are related to their anti-lipoperoxidant properties. Keywords: Experimental gastric ulcer; lipid peroxidation; medicinal plants; Quercus sp.; tannins; castalagin</style></abstract><accession-num><style face="normal" font="default" size="100%">12590500</style></accession-num><notes><style face="normal" font="default" size="100%">From Duplicate 2 (Effect of Tannins from Quercus suber and Quercus coccifera Leaves on Ethanol-Induced Gastric Lesions in Mice - Khennouf, Seddik; Benabdallah, Hassiba; Gharzouli, Kamel; Amira, Smain; Ito, Hideyuki; Kim, Tae-Hoon; Yoshida, Takashi; Gharzouli, Akila)</style></notes><research-notes><style face="normal" font="default" size="100%">From Duplicate 2 (Effect of Tannins from Quercus suber and Quercus coccifera Leaves on Ethanol-Induced Gastric Lesions in Mice - Khennouf, Seddik; Benabdallah, Hassiba; Gharzouli, Kamel; Amira, Smain; Ito, Hideyuki; Kim, Tae-Hoon; Yoshida, Takashi; Gharzouli, Akila)</style></research-notes></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Krizková, L</style></author><author><style face="normal" font="default" size="100%">Lopes, M H</style></author><author><style face="normal" font="default" size="100%">Polónyi, J</style></author><author><style face="normal" font="default" size="100%">Belicová, a</style></author><author><style face="normal" font="default" size="100%">Dobias, J</style></author><author><style face="normal" font="default" size="100%">Ebringer, L</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimutagenicity of a suberin extract from Quercus suber cork.</style></title><secondary-title><style face="normal" font="default" size="100%">Mutation research</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acridine Orange</style></keyword><keyword><style  face="normal" font="default" size="100%">Acridine Orange: toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimutagenic Agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimutagenic Agents: pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Euglena gracilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Euglena gracilis: drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Euglena gracilis: genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Euglena gracilis: radiation effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipids</style></keyword><keyword><style  face="normal" font="default" size="100%">Membrane Lipids</style></keyword><keyword><style  face="normal" font="default" size="100%">Membrane Lipids: pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutagenicity Tests</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutagenicity Tests: methods</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutagens</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutagens: toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Ofloxacin</style></keyword><keyword><style  face="normal" font="default" size="100%">Ofloxacin: toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Extracts: pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Shoots</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant Shoots: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Spectrophotometry, Ultraviolet</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxides</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxides: metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Trees</style></keyword><keyword><style  face="normal" font="default" size="100%">Trees: chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Ultraviolet Rays</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">1999</style></year></dates><volume><style face="normal" font="default" size="100%">446</style></volume><pages><style face="normal" font="default" size="100%">225-30</style></pages><isbn><style face="normal" font="default" size="100%">4217542577</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The possible protective effect of a suberin extract from Quercus suber cork on acridine orange (AO)-, ofloxacin- and UV radiation-induced mutagenicity (bleaching activity) in Euglena gracilis was examined. To our knowledge, the present results are the first attempt to analyse suberin in relation to mutagenicity of some chemicals. Suberin exhibits a significant dose-dependent protective effect against AO-induced mutagenicity and the concentration of 500 micrograms/ml completely eliminates the Euglena-bleaching activity of AO. The mutagenicity of ofloxacin is also significantly reduced in the presence of suberin (125, 250 and 500 micrograms/ml). However, the moderate protective effect of suberin on UV radiation-induced mutagenicity was observed only at concentrations 500 and 1000 micrograms/ml. Our data shows that suberin extract from Q. suber cork possess antimutagenic properties and can be included in the group of natural antimutagens acting in a desmutagenic manner.</style></abstract><accession-num><style face="normal" font="default" size="100%">10635345</style></accession-num></record></records></xml>