Home /Effect of Tannins from Quercus suber and Quercus coccifera Leaves on Ethanol-Induced Gastric Lesions in Mice

Effect of Tannins from Quercus suber and Quercus coccifera Leaves on Ethanol-Induced Gastric Lesions in Mice

TitleEffect of Tannins from Quercus suber and Quercus coccifera Leaves on Ethanol-Induced Gastric Lesions in Mice
Publication TypeJournal Article
Year of Publication2003
AuthorsKhennouf, S., Benabdallah H., Gharzouli K., Amira S., Ito H., Kim T-H., Yoshida T., & Gharzouli A.
JournalJournal of Agricultural and Food Chemistry
Volume51
Pagination1469-1473
Accession Number12590500
KeywordsAcetone, Animals, Biphenyl Compounds, castalagin, Catechols, Catechols: therapeutic use, Ethanol, Experimental gastric ulcer, Hydrolyzable Tannins, lipid peroxidation, Lipid Peroxidation: drug effects, Male, Medicinal plants, Mice, Plant Extracts, Plant Extracts: chemistry, Plant Extracts: therapeutic use, Plant Leaves, Plant Leaves: chemistry, Quercus, Quercus sp., Quercus: chemistry, Rabbits, Stomach Ulcer, Stomach Ulcer: chemically induced, Stomach Ulcer: prevention & control, Tannins, Tannins: pharmacology, Tannins: therapeutic use
Abstract

The gastroprotective effects of 70% acetone extracts of Quercus suber and Quercus coccifera leaves and of tannins (pedunculagin, castalagin, phillyraeoidin A, and acutissimin B) purified from these extracts were examined in the mouse using the ethanol-induced gastric ulcer model. Both extracts (25, 50, and 100 mg/kg), given orally, prevented the formation of ethanol-induced lesions in the stomach. The percent protection varied between 68 and 91%. Purified tannins (50 mg/kg) were also effective in protecting the stomach against ethanol, and the percent protection varied from 66 to 83%. Castalagin was the most potent. Both extracts and all of the tannins tested (10, 25, and 50 ?g/mL) strongly inhibited (55?65%) the lipid peroxidation of rabbit brain homogenate. These results suggest that the gastroprotective effects of extracts of Q. suber and Q. coccifera leaves and the purified tannins in this experimental model are related to their anti-lipoperoxidant properties. Keywords: Experimental gastric ulcer; lipid peroxidation; medicinal plants; Quercus sp.; tannins; castalagin